Histidine-specific bioconjugation <i>via</i> visible-light-promoted thioacetal activation-Reference-Cited by-同舟云学术

Histidine-specific bioconjugation via visible-light-promoted thioacetal activation

Published:2022 Issue:28 Volume:13 Page:8289-8296
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wan Chuan¹,Wang Yuena¹,Lian Chenshan²,Chang Qi²,An Yuhao²,Chen Jiean²^ORCID,Sun Jinming¹,Hou Zhanfeng²,Yang Dongyan³,Guo Xiaochun¹,Yin Feng²,Wang Rui²^ORCID,Li Zigang¹²^ORCID

Affiliation:

1. State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China

2. Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, P. R. China

3. College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, P. R. China

Abstract

Functionalization of histidine residues in proteins via visible-light-promoted thioacetal activation is reported. ∼2000 proteins with reactive and exposed histidine residues from the MCF7 cell line are characterized using ABPP by this method.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Shenzhen Bay Laboratory

Science, Technology and Innovation Commission of Shenzhen Municipality

Shenzhen Fundamental Research and Discipline Layout project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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