Mechanistic study of the bismuth mediated fluorination of arylboronic esters and further rational design-Reference-Cited by-同舟云学术

Mechanistic study of the bismuth mediated fluorination of arylboronic esters and further rational design

Published:2022 Issue:37 Volume:12 Page:24208-24216
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Cai Jiali¹,Zhi Minna¹,Hu Junyuan¹,Pu Tingting¹,Guo Kai²^ORCID,Zhao Lili¹³^ORCID

Affiliation:

1. Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China

2. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, China

3. College of Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China

Abstract

DFT calculations disclosed the catalytic mechanism of the bismuth redox catalyzed fluorination of arylboronic esters. In addition, more efficient catalysts with the framework of tethered bis-anionic ligands were rationally designed.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Nanjing Tech University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA04296G

Reference52 articles.

1. Fluorine in Pharmaceuticals: Looking Beyond Intuition