Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition

Author:

Li Boyu12345ORCID,Gao Fengyun12345,Feng Xing12345,Sun Mengmeng12345,Guo Yifei12345,Wen Dongwa12345,Deng Yabo12345,Huang Jinqi678910,Wang Kairong12345,Yan Wenjin12345ORCID

Affiliation:

1. The Institute of Pharmacology

2. Key Laboratory of Preclinical Study for New Drugs of Gansu Province

3. School of Basic Medical Sciences

4. Lanzhou University

5. Lanzhou 730000

6. Key Laboratory for Cancer T-Cell Theranostics and Clinical Translation (CTCTCT) & Translational Medicine Research Center (TMRC)

7. Institute of Biomedical Research

8. School of Pharmaceutical Sciences

9. Xiamen University

10. Xiamen 361102

Abstract

The first organocatalyzed [3 + 2] cyclisation of N-2,2,2-trifluoroethylisatin ketimines with aurones has been developed.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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