Affiliation:
1. Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada
Abstract
In this manuscript, we report a new strategy to access α-(hetero)arylnitriles from malononitrile, a commodity chemical. The reaction proceeds through a one-pot decyanation (via transnitrilation) and subsequent nucleophilic aromatic substitution.
Funder
Ontario Research Foundation
Alfred P. Sloan Foundation
Ontario Ministry of Research, Innovation and Science
University of Toronto
Government of Ontario
Natural Sciences and Engineering Research Council of Canada
Ministry of Research and Innovation
Canada Research Chairs
Canada Foundation for Innovation
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry