Optimization of a liquid chromatography-tandem mass spectrometry method for the quantification of traces of taxanes in a Corylus avellana cell suspension medium-Reference-Cited by-同舟云学术

Optimization of a liquid chromatography-tandem mass spectrometry method for the quantification of traces of taxanes in a Corylus avellana cell suspension medium

Published:2015 Issue:23 Volume:5 Page:17976-17983
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Gallego Ana¹²³⁴,Jáuregui Olga⁵⁶⁷⁴,Moyano Elisabeth¹²³⁴,Palazón Javier⁸⁹¹⁰¹¹⁴,Casals Isidre⁵⁶⁷⁴,Bonfill Mercedes⁸⁹¹⁰¹¹⁴^ORCID

Affiliation:

1. Departament de Ciències Experimentals i de la Salut

2. Universitat Pompeu Fabra

3. Barcelona

4. Spain

5. Scientific & Technological Centers

6. Universitat de Barcelona (CCiTUB)

7. 08028 Barcelona

8. Laboratorio de Fisiología Vegetal

9. Facultad de Farmacia

10. Universidad de Barcelona

11. E-08028 Barcelona

Abstract

We developed a reliable HPLC-MS/MS method to quantify five of the most commercially important taxanes in a C. avellana cell suspension medium. Its linearity, intra- and inter-day precision, recovery, accuracy, LOD/LOQ and matrix effect were evaluated.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA00803D

Reference20 articles.

1. Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

2. Natural Taxanes: Developments Since 1828

3. Taxol: A Unique Antineoplastic Agent with Significant Activity in Advanced Ovarian Epithelial Neoplasms

4. Phase II Trial of Taxol, an Active Drug in the Treatment of Metastatic Breast Cancer

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