Sustainable chromatography (an oxymoron?)

Author:

Peterson Emily A.12,Dillon Barry345,Raheem Izzat67,Richardson Paul89,Richter Daniel89,Schmidt Rachel1011,Sneddon Helen F.101213

Affiliation:

1. Amgen

2. Cambridge, USA

3. Brixham Environmental Laboratory

4. AstraZeneca

5. Brixham, UK

6. Merck Research Laboratories

7. West Point, USA

8. Pfizer Global Research and Development

9. San Diego, USA

10. GlaxoSmithKline

11. Research Triangle Park, USA

12. Medicines Research Centre

13. Stevenage, UK

Abstract

This perspective details practical techniques for reducing the waste generated from chromatography within pharmaceutical drug discovery labs and additionally provides sustainable alternatives to flash chromatography.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Reference82 articles.

1. General methods for flash chromatography using disposable columns

2. Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

3. Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes

4. ACS GCI PR solvent selection guide 2011, http://surveys.acs.org/se.ashx?s=04BD76CC0E5496A7

5. Agency for Toxic Substances and Disease Registry (ATSDR) . Toxicological Profile for Methylene Chloride (Update). Draft for Public Comment . Public Health Service, U.S. Department of Health and Human Services , Atlanta, GA , 1998 , http://www.atsdr.cdc.gov/toxprofiles/tp14.pdf , (accessed April 2014)

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