Dynamic and thermodynamic impact of L94A, W100A, and W100L mutations on the D2 dopamine receptor bound to risperidone-Reference-Cited by-同舟云学术

Dynamic and thermodynamic impact of L94A, W100A, and W100L mutations on the D2 dopamine receptor bound to risperidone

Published:2022 Issue:53 Volume:12 Page:34359-34368
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Azam Faizul¹^ORCID,Bello Martiniano²^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Unaizah, 51911, Saudi Arabia

2. Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Diaz Mirón, S/N, Col. Casco de Santo Tomas, Ciudad de México 11340, Mexico

Abstract

DRD2 is an important receptor in the mediation of antipsychotic drugs but also in Parkinson medication, hyperprolactinemia, nausea and vomiting.

Funder

Qassim University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA06694G

Reference38 articles.

1. Dopamine Receptors: From Structure to Function

2. The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists

3. Chronic pharmacological manipulation of dopamine receptors in brain

4. The Physiology, Signaling, and Pharmacology of Dopamine Receptors

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