Design and synthesis of acetaminophen probe APAP-P1 for identification of the toxicity targets thioredoxin reductase-1 in HepaRG cells-Reference-Cited by-同舟云学术

Design and synthesis of acetaminophen probe APAP-P1 for identification of the toxicity targets thioredoxin reductase-1 in HepaRG cells

Published:2019 Issue:27 Volume:9 Page:15224-15228
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Shan¹²³⁴⁵^ORCID,Tian Yu¹²³⁴⁵,Lu Shan¹²³⁴⁵,Wang Ruiying¹²³⁴⁵,Shang Hai¹²³⁴⁵,Zhang Xuelian¹²³⁴⁵,Zhang Chenyang¹²³⁴⁵,Sun Guibo¹²³⁴⁵,Xu Xudong¹²³⁴⁵,Sun Xiaobo¹²³⁴⁵

Affiliation:

1. Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine

2. Institute of Medicinal Plant Development

3. Chinese Academy of Medical Sciences & Peking Union Medical College

4. Beijing 100193

5. P. R. China

Abstract

Drug-induced liver injury is one of the main causes of drug non-approval and drug withdrawal by the Food and Drug Administration (FDA).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA00483A

Reference27 articles.

1. Evaluation of DILI Predictive Hypotheses in Early Drug Development

2. Drug-induced liver injury: recent advances in diagnosis and risk assessment

3. Drug-induced liver injury: Mechanisms and test systems

4. Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?

5. Acetaminophen Toxicity

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