Semi-synthesis, α-amylase inhibition, and kinetic and molecular docking studies of arylidene-based sesquiterpene coumarins isolated from <i>Ferula tunetana</i> Pomel ex Batt-Reference-Cited by-同舟云学术

Semi-synthesis, α-amylase inhibition, and kinetic and molecular docking studies of arylidene-based sesquiterpene coumarins isolated from Ferula tunetana Pomel ex Batt

Published:2024 Issue:7 Volume:14 Page:4654-4665
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Baccari Wiem¹,Saidi Ilyes¹,Filali Insaf²,Znati Mansour¹,Lazrag Houda³,Tounsi Moncef⁴,Marchal Axel⁵⁶,Waffo-Teguo Pierre⁵⁶,Ben Jannet Hichem¹^ORCID

Affiliation:

1. University of Monastir, Faculty of Science of Monastir, Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Avenue of Environment, 5019 Monastir, Tunisia

2. Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia

3. University of Monastir, Higher Institute of Biotechnology of Monastir, Laboratory of Genetics, Biodiversity and Bioresources Valuation LR11S41, 5019 Monastir, Tunisia

4. Preparatory Year Deanship, Basic Science Department, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia

5. Université de Bordeaux, Institut des Sciences de la Vigne et du Vin, EA 4577, Unité de Recherche Œnologie 210 Chemin de Leysotte, CS50008, 33882 Villenave d’Ornon, France

6. Université de Bordeaux, Bordeaux INP, Bordeaux Sciences Agro, UMR 1366 OENOLOGIE, ISVV, 33140 Villenave d’Ornon, France

Abstract

Despite all the significant progress made to enhance the efficacy of the existing bank of drugs used to manage and cure type II diabetes mellitus, there is still a need to explore novel, effective bioactive compounds with fewer side effects.

Funder

Prince Sattam bin Abdulaziz University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA07540K

Reference37 articles.

1. Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends

2. Diabetes prediction using supervised machine learning

3. Anti-diabetic drugs recent approaches and advancements

4. Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase