Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries-Reference-Cited by-同舟云学术

Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries

Published:2016 Issue:10 Volume:7 Page:2020-2027
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Denton Kyle E.¹²³⁴⁵,Krusemark Casey J.¹²³⁴⁵

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology

2. College of Pharmacy

3. Purdue University and Purdue University Center for Cancer Research

4. West Lafayette

5. 47906 USA

Abstract

Enrichment of DNA-encoded ligands under stringent, protein-denaturing conditions is enabled by crosslinking with electrophilic or photoreactive groups.

Funder

Ralph W. and Grace M. Showalter Research Trust Fund

National Institutes of Health

National Cancer Institute

Purdue University

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00288A

Reference48 articles.

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4. Selection of Smart Small-Molecule Ligands: The Proof of Principle

5. Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment

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