Unprecedented inhibition of resistant penicillin bindingproteins by bis-2-oxoazetidinylmacrocycles-Reference-Cited by-同舟云学术

Unprecedented inhibition of resistant penicillin bindingproteins by bis-2-oxoazetidinylmacrocycles

Published:2012 Issue:3 Volume:3 Page:344-351
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sliwa Aline¹²³⁴⁵,Dive Georges⁶⁷⁸⁵,Zervosen Astrid⁹¹⁰¹¹⁵,Verlaine Olivier⁶⁷⁸⁵,Sauvage Eric⁶⁷⁸⁵,Marchand-Brynaert Jacqueline¹²³⁴⁵

Affiliation:

1. Institute of Condensed Matter and Nanosciences (IMCN)

2. Molecules, Solids and Reactivity (MOST)

3. Université Catholique de Louvain

4. Louvain-la-Neuve

5. Belgium

6. Centre d'ingénierie des Protéines (CIP)

7. Université de Liège

8. Sart-Tilman

9. Centre de Recherches du Cyclotron

10. B30, Université de Liège

11. Sart Tilman

Abstract

Bis-2-oxoazetidinyl macrocycles, obtained as unexpected products of RCM cyclizations, exhibit good activities against d,d-peptidase from Actinomadura R39 and revealed very promising activities against PBP2a from methicillin-resistant Staphylococcus aureus.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2012/MD/C2MD00251E

Reference25 articles.

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3. Penicillin-binding proteins and β-lactam resistance

4. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus

5. Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus

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