Chemical selectivity of nucleobase adduction relative to in vivo mutation sites on exon 7 fragment of p53 tumor suppressor gene-Reference-Cited by-同舟云学术

Chemical selectivity of nucleobase adduction relative to in vivo mutation sites on exon 7 fragment of p53 tumor suppressor gene

Published:2015 Issue:10 Volume:6 Page:5554-5563
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Malla Spundana¹²³⁴,Kadimisetty Karteek¹²³⁴,Fu You-Jun¹²³⁴,Choudhary Dharamainder⁵⁶⁷⁴,Jansson Ingela⁸⁶⁷⁴,Schenkman John B.⁸⁶⁷⁴,Rusling James F.¹²³⁴⁸

Affiliation:

1. Department of Chemistry

2. University of Connecticut

3. Storrs

4. USA

5. Department of Surgery

6. University of Connecticut Health Center

7. Farmington

8. Department of Cell Biology

Abstract

A 32-bp fragment of P53 gene reacted with benzo[a]pyrene metabolite BPDE was analyzed by LC-MS/MS. Chemically reactive sites were similar to frequently mutated codons in tumors.

Funder

National Institute of Environmental Health Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C5SC01403D

Reference68 articles.

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