Evaluation of botulinum toxin type A by bioassays and a validated reversed-phase liquid chromatography method-Reference-Cited by-同舟云学术

Evaluation of botulinum toxin type A by bioassays and a validated reversed-phase liquid chromatography method

Published:2016 Issue:3 Volume:8 Page:587-592
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

de Freitas G. W.¹²³,Perobelli R. F.¹²³,Maldaner F. P. S.¹²³,Xavier B.⁴²³,Dalmora D. A.⁵³,Schramm V. G.¹²³,Dalmora S. L.⁴²³

Affiliation:

1. Pós-Graduação em Ciências Farmacêuticas

2. Universidade Federal de Santa Maria

3. Brazil

4. Departamento de Farmácia Industrial

5. Complexo Hospitalar Santa Casa de Porto Alegre

Abstract

The biological potency of botulinum toxin type A (BoNTA) in biotechnology-derived products was assessed by the mouse LD₅₀ bioassay (MBA) and the T47D cell culture assay.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/AY/C5AY02283E

Reference30 articles.

1. Pharmacology of botulinum toxin

2. Botulinum Toxin—New Mechanisms, New Therapeutic Directions?

3. Botulinum toxin: Clinical use

4. Botulinum toxin: Chemistry, pharmacology, toxicity, and immunology

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