Enantioselective synthesis of tryptanthrin derivatives enabled by an asymmetric aza-Friedel

Enantioselective synthesis of tryptanthrin derivatives enabled by an asymmetric aza-Friedel–Crafts reaction

Published:2023 Issue:21 Volume:10 Page:5421-5427
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

You Yong¹^ORCID,Gan Guo-Ying¹,Duan Si-Yang¹,Zhang Yan-Ping¹,Li Qun²,Wang Zhen-Hua¹^ORCID,Zhao Jian-Qiang¹^ORCID,Liu Xiong-Li³^ORCID,Yuan Wei-Cheng¹^ORCID

Affiliation:

1. Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China

2. School of Materials and Environmental Engineering, Chengdu Technological University, Chengdu 611730, China

3. Guizhou Engineering Center for Innovative Traditional Chinese Medicine and Ethnic Medicine, College of Pharmacy, Guizhou University, Guiyang 550025, China

Abstract

A class of ketimines was first prepared and used in an asymmetric aza-Friedel–Crafts reaction for the highly enantioselective synthesis of tryptanthrin derivatives.

Funder

Chengdu University

National Natural Science Foundation of China

Natural Science Foundation of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00961K

Reference65 articles.

1. Natural Products as Sources of New Drugs from 1981 to 2014