The length of disulfide bond-containing linkages impacts the oral absorption and antitumor activity of paclitaxel prodrug-loaded nanoemulsions-Reference-Cited by-同舟云学术

The length of disulfide bond-containing linkages impacts the oral absorption and antitumor activity of paclitaxel prodrug-loaded nanoemulsions

Published:2021 Issue:23 Volume:13 Page:10536-10543
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Gao Yanlin¹²³⁴,Zuo Shiyi⁵²³⁴,Li Lingxiao⁵²³⁴,Liu Tian⁵²³⁴,Dong Fudan⁵²³⁴,Wang Xin⁵²³⁴,Zhang Xuanbo⁵²³⁴,He Zhonggui⁵²³⁴^ORCID,Zhai Yinglei⁶²³⁴,Sun Bingjun⁵²³⁴,Sun Jin⁵²³⁴^ORCID

Affiliation:

1. School of Pharmacy

2. Shenyang Pharmaceutical University

3. Shenyang 110016

4. China

5. Wuya College of Innovation

6. School of Medical Device

Abstract

Paclitaxel and three paclitaxel–citronellol prodrugs with different lengths of linkages are loaded into nanoemulsions. The lengths of linkages in the three prodrugs have impacts on oral absorption, drug release, and antitumor effects.

Funder

National Natural Science Foundation of China

Liaoning Revitalization Talents Program

National Postdoctoral Program for Innovative Talents

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR01359A

Reference22 articles.