Varying the hydrophobic core composition of polymeric nanoparticles affects NLRP3 inflammasome activation-Reference-Cited by-同舟云学术

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Varying the hydrophobic core composition of polymeric nanoparticles affects NLRP3 inflammasome activation

Published:2024 Issue:18 Volume:12 Page:4790-4805
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Malhotra Mehak¹,Chotaliya Dhruv¹,Debnath Maharshi¹,Patel Ruchi²,Kulkarni Ashish¹³^ORCID

Affiliation:

1. Department of Chemical Engineering, University of Massachusetts, Amherst, MA 01003, USA

2. Department of Pathology, UMass Chan Medical School-Baystate, Springfield, MA 01107, USA

3. Center for Bioactive Delivery, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA 01003, USA

Abstract

We have demonstrated the impact of supramolecular polymer nanoparticle (SNP) core composition on NLRP3 inflammasome activation, in vitro and in vivo proinflammatory responses, offering insights for designing nano-immunotherapies.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D4BM00580E

Reference40 articles.

1. Nanoparticle-based strategies for cancer immunotherapy and immunodiagnostics

2. Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation

3. Immune Response to Nanomaterials: Implications for Medicine and Literature Review

4. NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

5. Modulation of Immune Response Using Engineered Nanoparticle Surfaces

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