Inflammatory-stimuli-responsive turn-on NIR fluorogenic theranostic prodrug: adjuvant delivery of diclofenac and hydrogen sulfide attenuates acute inflammatory disorders-Reference-Cited by-同舟云学术

Inflammatory-stimuli-responsive turn-on NIR fluorogenic theranostic prodrug: adjuvant delivery of diclofenac and hydrogen sulfide attenuates acute inflammatory disorders

Published:2024 Issue:17 Volume:12 Page:4248-4261
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Sufian Abu¹^ORCID,Parihar Nidhi²^ORCID,Badirujjaman Md¹^ORCID,Barman Pallavi¹^ORCID,Kesarwani Rahul¹^ORCID,Pemmaraju Deepak B.²^ORCID,Bhabak Krishna P.¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India

2. Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research, Guwahati 781101, Assam, India

Abstract

ROS-responsive fluorogenic prodrug DCF-HS was developed for the delivery of the anti-inflammatory drug diclofenac and carbonyl sulfide (COS) with turn-on NIR fluorescence and the subsequent hydrolysis of COS to H2S by the enzyme carbonic anhydrase.

Funder

Indian Council of Medical Research

Technology Information, Forecasting and Assessment Council

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02552G

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