Quantitative LC-MS/MS method for nivolumab in human serum using IgG purification and immobilized tryptic digestion-Reference-Cited by-同舟云学术

Quantitative LC-MS/MS method for nivolumab in human serum using IgG purification and immobilized tryptic digestion

Published:2020 Issue:1 Volume:12 Page:54-62
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Abe Kazuki¹²³⁴,Shibata Kaito¹²³⁴,Naito Takafumi¹²³⁴^ORCID,Karayama Masato⁵²³⁴,Hamada Etsuko⁶²³⁴,Maekawa Masato⁶²³⁴,Yamada Yasuhide⁵²³⁴,Suda Takafumi⁷⁸²³⁴,Kawakami Junichi¹²³⁴

Affiliation:

1. Department of Hospital Pharmacy

2. Hamamatsu University School of Medicine

3. Hamamatsu 431-3192

4. Japan

5. Department of Clinical Oncology

6. Department of Laboratory Medicine

7. Second Division

8. Department of Internal Medicine

Abstract

A simple and rapid LC-MS/MS method for quantification of nivolumab in human serum using immobilized trypsin coupled to IgG purification.

Funder

Japan Research Foundation for Clinical Pharmacology

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AY/C9AY02087J

Reference28 articles.

1. Nivolumab in the treatment of metastatic squamous non-small cell lung cancer: a review of the evidence

2. Quantification of Patient-Specific Assay Interference in Different Formats of Enzyme-Linked Immunoassays for Therapeutic Monoclonal Antibodies

3. The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry

4. Immunopurification and Mass Spectrometric Quantification of the Active Form of a Chimeric Therapeutic Antibody in Human Serum

5. Validated LC–MS/MS analysis of immune checkpoint inhibitor Nivolumab in human plasma using a Fab peptide-selective quantitation method: nano-surface and molecular-orientation limited (nSMOL) proteolysis

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