Pictet–Spengler condensations using 4-(2-aminoethyl)coumarins

Author:

Sviripa Vitaliy M.12345ORCID,Fiandalo Michael V.6785,Begley Kristin L.92345ORCID,Wyrebek Przemyslaw92345,Kril Liliia M.92345,Balia Andrii G.92345,Parkin Sean R.101145ORCID,Subramanian Vivekanandan122345,Chen Xi13141516,Williams Alexander H.12345,Zhan Chang-Guo12345ORCID,Liu Chunming1734518ORCID,Mohler James L.678519ORCID,Watt David S.92345ORCID

Affiliation:

1. Department of Pharmaceutical Sciences

2. College of Pharmacy

3. University of Kentucky

4. Lexington

5. USA

6. Department of Experimental Therapeutics

7. Roswell Park Comprehensive Cancer Center

8. Buffalo

9. Center for Pharmaceutical Research and Innovation

10. Department of Chemistry

11. College of Arts and Sciences, University of Kentucky

12. NMR Center

13. College of Chemistry and Material Science

14. South Central University for Nationalities

15. Wuhan 430074

16. People's Republic of China

17. Lucille Parker Markey Cancer Center

18. Department of Molecular and Cellular Biochemistry

19. Department of Urology

Abstract

Amino-substituted coumarins undergo Pictet–Spengler condensations with 3-ketosteroids to afford spirocyclic androgens for the study 17-oxidoreductases for intracrine, androgen metabolism.

Funder

National Institutes of Health

American Cancer Society

U.S. Department of Defense

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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