DNA nanoclew templated spherical nucleic acids for siRNA delivery

Author:

Ruan Weimin12345ORCID,Zheng Meng12345,An Yang6345,Liu Yuanyuan12345,Lovejoy David B.78,Hao Mingcong12345,Zou Yan12345,Lee Albert78,Yang Shu78,Lu Yiqing12345,Morsch Marco78ORCID,Chung Roger78,Shi Bingyang12345ORCID

Affiliation:

1. International Joint Center for Biomedical Innovation

2. School of Life Sciences

3. Henan University

4. Kaifeng

5. P. R. China

6. School of Basic Medical Sciences

7. Motor Neuron Disease Research Centre, Department of Biomedical Sciences, Faculty of Medicine and Health Science, Macquarie University

8. Australia

Abstract

A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed DNA nanoclew (DC).

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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