Polymorphism in anti-hyperammonemic agent N-carbamoyl-l-glutamic acid-Reference-Cited by-同舟云学术

Polymorphism in anti-hyperammonemic agent N-carbamoyl-l-glutamic acid

Published:2015 Issue:28 Volume:17 Page:5252-5265
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Maddileti D.¹²³⁴⁵,Nangia Ashwini¹²³⁴⁵

Affiliation:

1. School of Chemistry

2. University of Hyderabad

3. Prof. C. R. Rao Road

4. Central University PO

5. Hyderabad 500 046, India

Abstract

Solid form screen of anti-hyperammonemic drug carglumic acid (CGA) resulted in two polymorphs, Form-I and Form-II. The crystal structure of Form-I is sustained by an acid catemer synthon, whereas Form-II has an acid–amide heterosynthon. Slurry grinding, thermal stress, stability measurements, and DVS analysis confirm the thermodynamic stability of Form-I.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CE/C5CE00116A

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