Self-assembly of mitochondria-specific peptide amphiphiles amplifying lung cancer cell death through targeting the VDAC1–hexokinase-II complex-Reference-Cited by-同舟云学术

Self-assembly of mitochondria-specific peptide amphiphiles amplifying lung cancer cell death through targeting the VDAC1–hexokinase-II complex

Published:2019 Issue:30 Volume:7 Page:4706-4716
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Liu Dan¹²³⁴⁵,Angelova Angelina⁶⁷⁸⁹¹⁰^ORCID,Liu Jianwen¹¹¹²⁴⁵¹³,Garamus Vasil M.¹⁴¹⁵¹⁶¹⁷,Angelov Borislav¹⁸¹⁹²⁰²¹²²,Zhang Xinlei¹²³⁴⁵,Li Yawen¹²³⁴⁵,Feger Guillaume⁶⁷⁸⁹¹⁰,Li Na²³²⁴¹³,Zou Aihua¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Key Laboratory of Functional Materials Chemistry

2. State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry

3. School of Chemistry and Molecular Engineering

4. East China University of Science and Technology

5. Shanghai 200237

6. Institut Galien Paris-Sud

7. CNRS UMR 8612

8. LabEx LERMIT

9. Univ. Paris-Sud

10. Université Paris-Saclay

11. State Key Laboratory of Bioreactor Engineering & Shanghai Key Laboratory of New Drug Design

12. School of Pharmacy

13. P. R. China

14. Helmholtz-Zentrum Geesthacht

15. Centre for Materials and Coastal Research

16. D-21502 Geesthacht

17. Germany

18. Institute of Physics

19. ELI Beamlines

20. Academy of Sciences of the Czech Republic

21. CZ-18221 Prague

22. Czech Republic

23. National Center for Protein Science Shanghai and Shanghai Institute of Biochemistry and Cell Biology

24. Shanghai 200120

Abstract

Novel cell-penetrating peptides self-assemble into ellipsoid-shape nanostructures which amplified the apoptotic stimuli by weakening the VDAC1–HK-II interaction.

Funder

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2019/TB/C9TB00629J

Reference91 articles.

1. Mitochondria as therapeutic targets for cancer chemotherapy