Total synthesis and mechanism of action of the antibiotic armeniaspirol A-Reference-Cited by-同舟云学术

Total synthesis and mechanism of action of the antibiotic armeniaspirol A

Published:2021 Issue:48 Volume:12 Page:16023-16034
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Arisetti Nanaji¹²,Fuchs Hazel L. S.¹^ORCID,Coetzee Janetta²³,Orozco Manuel³,Ruppelt Dominik⁴,Bauer Armin⁵^ORCID,Heimann Dominik¹^ORCID,Kuhnert Eric¹^ORCID,Bhamidimarri Satya P.⁶,Bafna Jayesh A.⁶,Hinkelmann Bettina¹,Eckel Konstantin⁷^ORCID,Sieber Stephan A.⁷³^ORCID,Müller Peter P.¹^ORCID,Herrmann Jennifer²³,Müller Rolf²³^ORCID,Winterhalter Mathias⁶^ORCID,Steinem Claudia⁴⁸^ORCID,Brönstrup Mark¹²⁹^ORCID

Affiliation:

1. Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany

2. German Centre for Infection Research, Partner Site Hannover-Braunschweig, Germany

3. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland University Campus E8.1, 66123 Saarbrücken, Germany

4. Georg-August-Universität Göttingen, Institute of Organic and Biomolecular Chemistry, Tammannstraße 2, 37077 Göttingen, Germany

5. Sanofi R&D, Industriepark Höchst, 65926 Frankfurt, Germany

6. Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany

7. Department of Chemistry, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technische Universität München, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany

8. Max-Planck-Institute for Dynamics and Self Organization, Am Faßberg 17, 37077 Göttingen, Germany

9. Center for Biomolecular Drug Research (BMWZ), Leibniz Universität, 30159 Hannover, Germany

Abstract

The antibiotic armeniaspirol A depolarized bacterial and mammalian cell membranes through a protonophore activity, that accounts for its potent antibiotic effects. A total synthesis of (±) armeniaspirol A was achieved in six steps.

Funder

Helmholtz Association

Deutsches Zentrum für Infektionsforschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC04290D

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