Design, postpolymerization conjugation and self-assembly of a di-block copolymer-based prodrug for tumor intracellular acid-triggered DOX release-Reference-Cited by-同舟云学术

Design, postpolymerization conjugation and self-assembly of a di-block copolymer-based prodrug for tumor intracellular acid-triggered DOX release

Published:2019 Issue:37 Volume:7 Page:5640-5647
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Dong Yuman¹²³⁴⁵,Du Pengcheng¹²³⁴⁵^ORCID,Pei Mingliang¹²³⁴⁵,Liu Peng¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry

2. College of Chemistry and Chemical Engineering

3. Lanzhou University

4. Lanzhou 730000

5. People's Republic of China

Abstract

A novel di-block copolymer-based prodrug was designed by atom transfer radical polymerization (ATRP) of glycidyl methacrylate (GMA) with a polyethylene glycol-based initiator (PEG-Br), postpolymerization aldehyde-modification, and doxorubicin (DOX) conjugation via an acid-labile imine bond.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2019/TB/C9TB01511F

Reference39 articles.

1. Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery

2. Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies

3. Self-assembling prodrugs

4. Reduction Responsive Self-Assembled Nanoparticles Based on Disulfide-Linked Drug–Drug Conjugate with High Drug Loading and Antitumor Efficacy

5. pH-responsive polymer–drug conjugates: Design and progress

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