Development of CBAP-BPyne, a probe for γ-secretase and presenilinase-Reference-Cited by-同舟云学术

Development of CBAP-BPyne, a probe for γ-secretase and presenilinase

Author:

Gertsik Natalya¹²³⁴⁵,Ballard T. Eric⁶⁷⁸⁴⁶,am Ende Christopher W.⁶⁹¹⁰⁴,Johnson Douglas S.⁶⁷⁸⁴,Li Yue-Ming¹²³⁴

Affiliation:

1. Molecular Pharmacology and Chemistry Program

2. Memorial Sloan-Kettering Cancer Center

3. New York

4. USA

5. Biochemistry and Molecular Biology Program

6. Pfizer Worldwide Research and Development

7. Neuroscience Medicinal Chemistry and Chemical Biology

8. Cambridge

9. Neuroscience Medicinal Chemistry

10. Groton

Abstract

CBAP-BPyne, a dual presenilinase and γ-secretase clickable probe, provides a novel means to investigate the mechanism of endoproteolysis.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

Reference28 articles.

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