KnowVolution of prodigiosin ligase PigC towards condensation of short-chain prodiginines-Reference-Cited by-同舟云学术

KnowVolution of prodigiosin ligase PigC towards condensation of short-chain prodiginines

Published:2021 Issue:8 Volume:11 Page:2805-2815
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Brands Stefanie¹²³⁴⁵^ORCID,Brass Hannah U. C.⁶²⁷⁸⁵^ORCID,Klein Andreas S.⁶²⁷⁸⁵^ORCID,Sikkens Jarno G.¹²³⁴⁵,Davari Mehdi D.¹²³⁴⁵^ORCID,Pietruszka Jörg⁶²⁷⁸⁵^ORCID,Ruff Anna Joëlle¹²³⁴⁵^ORCID,Schwaneberg Ulrich¹²³⁴⁵^ORCID

Affiliation:

1. Lehrstuhl für Biotechnologie

2. Bioeconomy Science Center (BioSC)

3. RWTH Aachen University

4. 52074 Aachen

5. Germany

6. Institute of Bioorganic Chemistry

7. Heinrich Heine University Düsseldorf

8. 52426 Jülich

Abstract

One round of KnowVolution enhanced the catalytic activity of prodigiosin ligase PigC with short-chain monopyrroles, opening access to anticancer prodiginines.

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CY/D0CY02297G

Reference68 articles.

1. Characterization of a prodigiosin synthetase PigC from Serratia marcescens jx-1 and its application in prodigiosin analogue synthesis

2. Chemoenzymatic synthesis of prodigiosin analogues—exploring the substrate specificity of PigC

3. Characterisation of PigC and HapC, the prodigiosin synthetases from Serratia sp. and Hahella chejuensis with potential for biocatalytic production of anticancer agents

4. The biosynthesis and regulation of bacterial prodiginines

5. Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products

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