Synthesis of indoles, benzofurans, and related heterocycles via an acetylene-activated SNAr/intramolecular cyclization cascade sequence in water or DMSO-Reference-Cited by-同舟云学术

Synthesis of indoles, benzofurans, and related heterocycles via an acetylene-activated SNAr/intramolecular cyclization cascade sequence in water or DMSO

Published:2015 Issue:8 Volume:13 Page:2273-2284
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hudson R.¹²³⁴,Bizier N. P.⁵⁶⁷⁴,Esdale K. N.¹²³⁴,Katz J. L.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Colby College

3. Waterville

4. USA

5. Division of Natural Sciences

6. Daemen College

7. Amherst

Abstract

The synthesis of 2-substituted indoles and benzofurans was achieved by nucleophilic aromatic substitution, followed by subsequent 5-endo-dig cyclization between the nucleophile and an ortho acetylene.

Funder

Camille and Henry Dreyfus Foundation

Division of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02549K

Reference103 articles.

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