Ground-state intramolecular proton transfer inhibits the selective methylation on quinoline and pyridine derivatives-Reference-Cited by-同舟云学术

Ground-state intramolecular proton transfer inhibits the selective methylation on quinoline and pyridine derivatives

Published:2023 Issue:15 Volume:25 Page:10599-10603
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Chanmungkalakul Supphachok¹^ORCID,Huang Shiqing¹²,Wu Xia¹^ORCID,Ang Esther Cai Xia³,Yang Zi-Qi³,Li Yongxin³,Yan Xiaoyu²^ORCID,Tan Choon-Hong³^ORCID,Tan Davin¹,Liu Xiaogang¹^ORCID

Affiliation:

1. Fluorescence Research Group, Singapore University of Technology and Design, 8 Somapah Road, 487372 Singapore, Singapore

2. Department of Chemistry, Renmin University of China, 100872 Beijing, China

3. School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 637459 Singapore, Singapore

Abstract

Methylation is a crucial step in organic synthesis, and achieving chemoselectivity in this reaction remains a challenge. Our study provided insights into the N-methylation mechanism and its selectivity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CP/D3CP00123G

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