C-Terminal modification of polytheonamide B uncouples its dual functions in MCF-7 cancer cells-Reference-Cited by-同舟云学术

C-Terminal modification of polytheonamide B uncouples its dual functions in MCF-7 cancer cells

Published:2023 Issue:26 Volume:59 Page:3914-3917
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Xue Yun-Wei¹,Miura Kensuke¹,Itoh Hiroaki¹^ORCID,Inoue Masayuki¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

Abstract

Polytheonamide B is a large natural product that forms an ion channel in the plasma and lysosomal membranes. Herein, we report the uncoupling of the dual functions of polytheonamide B by synthetically incorporating a tertiary amine at the C-terminus.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D2CC05915K

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