The critical role of ligand topology: strikingly different properties of Gd(<scp>iii</scp>) complexes with regioisomeric AAZTA derivatives-Reference-Cited by-同舟云学术

The critical role of ligand topology: strikingly different properties of Gd(iii) complexes with regioisomeric AAZTA derivatives

Published:2022 Issue:10 Volume:9 Page:2271-2283
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Martinelli Jonathan¹^ORCID,Boccalon Mariangela²^ORCID,Horvath David²³^ORCID,Esteban-Gomez David⁴^ORCID,Platas-Iglesias Carlos⁴^ORCID,Baranyai Zsolt²^ORCID,Tei Lorenzo¹^ORCID

Affiliation:

1. Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “A. Avogadro”, Viale T. Michel 11, 15121 Alessandria, Italy

2. Bracco Research Centre, Bracco Imaging S.p.A., Via Ribes 5, 10010, Colleretto Giacosa, Italy

3. University of Debrecen, Faculty of Science and Technology, Department of Physical Chemistry, Doctoral School of Chemistry, Debrecen, Hungary

4. Universidade da Coruña, Centro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Facultade de Ciencias, 15071, A Coruña, Galicia, Spain

Abstract

Two regioisomeric Gd(III) complexes with heptadentate AAZTA-like ligands show different hydration state (q = 1 and 2) and astonishingly different thermodynamic stability and dissociation kinetics.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QI/D2QI00451H

Reference59 articles.

1. [Gd-AAZTA]-: A New Structural Entry for an Improved Generation of MRI Contrast Agents

2. 68Ga, 44Sc and 177Lu-labeled AAZTA5-PSMA-617: synthesis, radiolabeling, stability and cell binding compared to DOTA-PSMA-617 analogues

3. Instant kit preparation of 68Ga-radiopharmaceuticals via the hybrid chelator DATA: clinical translation of [68Ga]Ga-DATA-TOC

4. AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents

5. Synthesis, radiolabeling, and pre-clinical evaluation of [44Sc]Sc-AAZTA conjugate PSMA inhibitor, a new tracer for high-efficiency imaging of prostate cancer

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