Innovation of 6-sulfonamide-2<i>H</i>-chromene derivatives as antidiabetic agents targeting α-amylase, α-glycosidase, and PPAR-γ inhibitors with <i>in silico</i> molecular docking simulation-Reference-Cited by-同舟云学术

Innovation of 6-sulfonamide-2H-chromene derivatives as antidiabetic agents targeting α-amylase, α-glycosidase, and PPAR-γ inhibitors with in silico molecular docking simulation

Published:2024 Issue:22 Volume:14 Page:15691-15705
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Thabet Hamdy Khamees¹^ORCID,Ragab Ahmed²^ORCID,Imran Mohd³,Hamdy Helal Mohamed¹,Ibrahim Alaqel Saleh³,Alshehri Ahmed⁴⁵,Ash Mohd Abida³,Alshammari Saleh Saad¹,Ammar Yousry A.²^ORCID,Abusaif Moustafa S.²^ORCID

Affiliation:

1. Department of Chemistry, College of Sciences and Arts, Northern Border University, Rafha, 91911, Saudi Arabia

2. Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt

3. Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia

4. Department of Pharmacology and Toxicology, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia

5. Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, King Faisal Road, Dammam 31441, Saudi Arabia

Abstract

A new series of 2-imino or 2-oxo-2H-chromene-6-sulfonamide derivatives 2–9 were designed and synthesized and evaluated for anti-diabetic activity.

Funder

Northern Border University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA02143F

Reference67 articles.

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4. The Prevalence and Presentation Pattern of Diabetes Mellitus in Patients at Imo State University Teaching Hospital (IMSUTH) Orlu and Imo State Specialist Hospital (IMSSH) Umuguma Owerri (A 10-Year Retrospective Study: 1st November 2004 to 31st October 2013)

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