Synthesis and antiproliferative potency of 1,3,4-thiadiazole and 1,3-thiazolidine-4-one based new binary heterocyclic molecules: <i>in vitro</i> cell-based anticancer studies-Reference-Cited by-同舟云学术

Synthesis and antiproliferative potency of 1,3,4-thiadiazole and 1,3-thiazolidine-4-one based new binary heterocyclic molecules: in vitro cell-based anticancer studies

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Maji Avik¹^ORCID,Himaja Ambati²,Nikhitha Sripathi²^ORCID,Rana Soumitra³,Paul Abhik¹^ORCID,Samanta Ajeya¹,Shee Uday⁴,Mukhopadhyay Chhanda³^ORCID,Ghosh Balaram²^ORCID,Maity Tapan Kumar¹^ORCID

Affiliation:

1. Synthetic and Natural Products Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, West Bengal, India

2. Epigenetic Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Hyderabad Campus, Hyderabad-500078, India

3. Department of Chemistry, University of Calcutta, Kolkata-700009, West Bengal, India

4. Department of Chemistry, Jadavpur University, Kolkata-700032, West Bengal, India

Abstract

This research reports the in vitro anticancer potency of 1,3,4-thiadiazole-2-yl-imino-thiazolidine-4-one based heterocyclic molecules. The compound 6e induced apoptosis of MCF-7 cells via ROS generation, cell shrinkage, and nuclear fragmentation.

Funder

Rashtriya Uchchatar Shiksha Abhiyan

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00279B

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4. Recent developments and biological activities of thiazolidinone derivatives: A review

5. 4-Thiazolidinones: The advances continue…