Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions
Author:
Affiliation:
1. Organic and Inorganic Chemistry Department
2. University of Oviedo
3. 33006 Oviedo
4. Spain
5. School of Chemistry
6. Manchester Institute of Biotechnology
7. University of Manchester
8. Manchester
9. UK
Abstract
A transaminase-catalyzed dynamic kinetic resolution is described for the stereoselective synthesis of a series of α-alkyl-β-amino amides.
Funder
Secretaría de Estado de Investigación, Desarrollo e Innovación
Publisher
Royal Society of Chemistry (RSC)
Subject
Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2019/CY/C9CY01004A
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2. Design, synthesis, and biological evaluation of triazolopiperazine-based β-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors
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4. Discovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes
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