A quantum mechanics and molecular mechanics study of bis-thiosemicarbazones with strong antiplasmodial properties as Fe(<scp>iii</scp>)-selective chelators and inhibitors of hemozoin formation-Reference-Cited by-同舟云学术

A quantum mechanics and molecular mechanics study of bis-thiosemicarbazones with strong antiplasmodial properties as Fe(iii)-selective chelators and inhibitors of hemozoin formation

Published:2024 Issue:13 Volume:48 Page:5636-5648
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Nkungli Nyiang Kennet¹^ORCID,Aponglen Godfred Ayimele¹²,Tasheh Stanley Numbonui¹,Hassan Abrar Ul³⁴^ORCID,Ghogomu Julius Numbonui¹⁵

Affiliation:

1. Department of Chemistry, Faculty of Science, The University of Bamenda, P. O. Box 39, Bambili-Bamenda, Cameroon

2. Department of Chemistry, Faculty of Science, University of Buea, P. O. Box 63, Buea, Cameroon

3. School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China

4. Lunan Research Institute, Beijing Institute of Technology, Zhengtai Road, Tengzhou 888, China

5. Department of Chemistry, Faculty of Science, University of Dschang, P. O. Box 67, Dschang, Cameroon

Abstract

Bis-thiosemicarbazones with strong antiplasmodial properties are found to exert their therapeutic effects through Fe(iii)-selective chelation and inhibition of hemozoin formation in plasmodium parasites.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NJ/D3NJ05347D

Reference47 articles.

1. World malaria report 2022, 2022

2. Computational insights into the inhibition of β-haematin crystallization by antimalarial drugs

3. A systematic review on anti-malarial drug discovery and antiplasmodial potential of green synthesis mediated metal nanoparticles: overview, challenges and future perspectives

4. Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites