Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities-Reference-Cited by-同舟云学术

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

Published:2021 Issue:11 Volume:38 Page:2041-2065
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Caesar Lindsay K.¹^ORCID,Montaser Rana¹^ORCID,Keller Nancy P.²,Kelleher Neil L.¹³^ORCID

Affiliation:

1. Department of Chemistry, Northwestern University, Evanston, IL, USA

2. Department of Medical Microbiology and Immunology and Bacteriology, University of Wisconsin–Madison, Madison, WI, USA

3. Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA

Abstract

Here we provide a comprehensive guide for studying natural product biosynthesis using genomics, metabolomics, and their integrated datasets. We emphasize integrated strategies and provide a critical outlook on remaining challenges in the field.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NP/D1NP00036E

Reference218 articles.

1. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

2. Historical review of medicinal plants′ usage

3. Natural products for human health: an historical overview of the drug discovery approaches

4. Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents

5. Confronting the Challenges of Natural Product-Based Antifungal Discovery

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