Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins
Author:
Affiliation:
1. The University of Queensland
2. Faculty of Medicine
3. School of Biomedical Sciences
4. Brisbane
5. Australia
6. The University of Western Australia
7. School of Molecular Sciences
8. Crawley
Abstract
SFTI-1 and related peptide natural products emerge from a hiding place in seed storage proteins to inspire pharmaceutical design.
Funder
Australian Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/NP/C7NP00066A
Reference66 articles.
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3. Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition
4. Disulfide Bond Mutagenesis and the Structure and Function of the Head-to-Tail Macrocyclic Trypsin Inhibitor SFTI-1,
5. Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure
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