Probing the methotrexate–protein interactions by proteomics and thermostability assay for drug resistance study
Author:
Affiliation:
1. Key Laboratory Molecular Enzymology and Engineering
2. The Ministry of Education
3. National Engineering Laboratory of AIDS Vaccine
4. School of Life Sciences
5. Jilin University
Abstract
Quantitative proteomics combined with thermostability assay provide a novel strategy for the study of mechanisms on drug action and resistance.
Funder
National Natural Science Foundation of China
Program for New Century Excellent Talents in University
Publisher
Royal Society of Chemistry (RSC)
Subject
General Engineering,General Chemical Engineering,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/AY/D0AY02099K
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1. Revealing promiscuous drug–target interactions by chemical proteomics
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