An extracellular vesicle microRNA-initiated 3D DNAzyme motor for colorectal cancer diagnosis-Reference-Cited by-同舟云学术

An extracellular vesicle microRNA-initiated 3D DNAzyme motor for colorectal cancer diagnosis

Published:2024 Issue:15 Volume:149 Page:3910-3919
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Fan Qian¹²,Sun Xu-Hong¹,Wu Na¹³,Wang Yuan-He⁴,Wang Jian-Hua¹^ORCID,Yang Ting¹^ORCID

Affiliation:

1. Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Box 332, Shenyang 110819, China

2. Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

3. Institute of Precision Medicine, Fujian Medical University, Fujian 350004, China

4. Department of Gastrointestinal Cancer, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, Shenyang 110042, China

Abstract

Combining target-initiated 3D DNAzyme motors with single-molecule imaging enables intuitive, sensitive and rapid detection of different miRNAs. Dual miRNA detection of EVs using this method is effective for clinical diagnosis of colorectal cancer.

Funder

National Natural Science Foundation of China

Liaoning Revitalization Talents Program

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D4AN00635F

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