Solvent controlled synthesis of 2,3-diarylepoxy indenones and α-hydroxy diarylindanones and their evaluation as inhibitors of DNA alkylation repair-Reference-Cited by-同舟云学术

Solvent controlled synthesis of 2,3-diarylepoxy indenones and α-hydroxy diarylindanones and their evaluation as inhibitors of DNA alkylation repair

Published:2022 Issue:29 Volume:20 Page:5820-5835
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Negi Rollania¹,Jena Tapan Kumar¹,Jyoti ¹,Tuti Nikhil Kumar²,Anindya Roy²^ORCID,Khan Faiz Ahmed¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi – 502 285, Sangareddy, Telangana, India

2. Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi – 502 285, Sangareddy, Telangana, India

Abstract

A serendipitous synthesis of indanones is reported; one of the compounds, 2h, showed the lowest IC50 reported so far against the DNA repair enzyme AlkB.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00595F

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