Involvement of ROS-mediated mitochondrial dysfunction and SIRT3 down-regulation in tris(2-chloroethyl)phosphate-induced cell cycle arrest

Author:

Zhang Wenjuan12345,Zhang Youjian12345,Xu Tian12345,Wang Zhiyuan12345,Wang Jing12345,Xiong Wei12345,Lu Wenhong12345,Zheng Hongyan12345,Yuan Jing12345

Affiliation:

1. Department of Occupational and Environmental Health

2. Ministry of Education & Ministry of Environmental Protection

3. and State Key Laboratory of Environmental Health (Incubating)

4. School of Public Health

5. Tongji Medical College

Abstract

TCEP induced G2/M cell cycle arrest and mitochondrial dysfunction through enhancement of mitochondrial oxidative stress and SIRT3 down-regulation in Chang liver cells.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

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