Conductive gradient hydrogels allow spatial control of adult stem cell fate

Author:

Song Shang123,McConnell Kelly W.1ORCID,Shan Dingying1,Chen Cheng4,Oh Byeongtaek1,Sun Jindi2,Poon Ada S. Y.4,George Paul M.15ORCID

Affiliation:

1. Department of Neurology and Neurological Sciences, Stanford University, School of Medicine, 300 Pasteur Dr, MC5778 Stanford Stroke Center, Stanford, CA 94305-5778, USA

2. Department of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA

3. Departments of Neuroscience GIDP, Materials Science and Engineering, BIO5 Institute, The University of Arizona, Tucson, AZ, USA

4. Department of Electrical Engineering, Stanford University, Stanford, CA, USA

5. Stanford Stroke Center and Stanford University School of Medicine, Stanford, CA, USA

Abstract

Conductive gradient hydrogels (CGGs) allow preferential differentiation of human mesenchymal stem cells (hMSCs) toward oligodendrocyte lineage in the center while neuronal lineage at the edge of the scaffold under electrical stimulation.

Funder

National Institutes of Health

Alliance for Regenerative Rehabilitation Research and Training

University of Arizona

Publisher

Royal Society of Chemistry (RSC)

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