The effect of backbone flexibility on site-selective modification of macrocycles-Reference-Cited by-同舟云学术

The effect of backbone flexibility on site-selective modification of macrocycles

Published:2016 Issue:43 Volume:14 Page:10230-10237
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Scully Conor C. G.¹²³⁴⁵,White Christopher J.¹²³⁴⁵,Yudin Andrei K.¹²³⁴⁵

Affiliation:

1. Davenport Research Laboratories

2. Department of Chemistry

3. University of Toronto

4. Toronto

5. Canada

Abstract

The interplay of rotatable backbone torsions determines the ring-opening regioselectivity of electrophilic aziridines in macrocyclic peptide scaffolds.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01778A

Reference44 articles.

1. Role of Frontier Orbitals in Chemical Reactions

2. Scales of Nucleophilicity and Electrophilicity: A System for Ordering Polar Organic and Organometallic Reactions

3. Torsional strain involving partial bonds. The stereochemistry of the lithium aluminium hydride reduction of some simple open-chain ketones

4. Allylic 1,3-strain as a controlling factor in stereoselective transformations

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