Discovery and structure–activity relationship study of novel isoxazole-based small molecules targeting Zika virus infections-Reference-Cited by-同舟云学术

Discovery and structure–activity relationship study of novel isoxazole-based small molecules targeting Zika virus infections

Published:2024 Issue:8 Volume:15 Page:2792-2805
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Girmay Berehe Solomon¹²^ORCID,Ayele Sileshi Abera¹²^ORCID,Abbas Syed Azeem¹²^ORCID,Jang Su San¹^ORCID,Jung Eunhye¹^ORCID,Shin Jin Soo¹^ORCID,Han Soo Bong¹²^ORCID,Kim Hyejin¹²³^ORCID

Affiliation:

1. Infectious Diseases Therapeutic Research Center, Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea

2. Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon 34113, Republic of Korea

3. School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea

Abstract

This study explores novel isoxazole-based small molecules, identifying compound 7l with potent antiviral activity against Zika virus (ZIKV) and an improved safety profile in vitro, highlighting its potential as a promising candidate for therapeutic development.

Funder

Korea Research Institute of Chemical Technology

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00240G

Reference27 articles.

1. Dengue

2. Fatal Sickle Cell Disease and Zika Virus Infection in Girl from Colombia

3. Zika Virus (I). Isolations and serological specificity

4. Zika virus : A report on three cases of human infection during an epidemic of jaundice in Nigeria

5. Zika Virus in Gabon (Central Africa) – 2007: A New Threat from Aedes albopictus?