A method for estimation of plasma protein binding using diffusion ordered NMR spectroscopy (DOSY)-Reference-Cited by-同舟云学术

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A method for estimation of plasma protein binding using diffusion ordered NMR spectroscopy (DOSY)

Published:2024 Issue:7 Volume:15 Page:2372-2379
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Taylor Rachel¹,Swift Thomas²^ORCID,Wilkinson David³,Afarinkia Kamyar¹⁴^ORCID

Affiliation:

1. Institute of Cancer Therapeutics, University of Bradford, Richmond Road, BD7 1DP, UK

2. Polymer and Biomaterials Laboratories, School of Chemistry and Bioscience, University of Bradford, Richmond Road, BD7 1DP, UK

3. Labcorp Drug Development, Otley Rd, Harrogate, HG3 1PY, UK

4. School of Medicine and Biosciences, University of West London, Saint Mary's Road, London W5 5RF, UK

Abstract

We describes a fast and simple method for quantitative determination of plasma protein binding of drug molecules using diffusion ordered spectroscopy (DOSY).

Funder

University of Bradford

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00244J

Reference47 articles.

1. Proteins and antibodies in serum, plasma, and whole blood—size characterization using asymmetrical flow field-flow fractionation (AF4)

2. A high confidence, manually validated human blood plasma protein reference set

3. Ontogeny of plasma proteins, albumin and binding of diazepam, cyclosporine, and deltamethrin

4. Relevance of albumin in modern critical care medicine

5. Liver Function Tests “Gone Viral”: Acute Hepatitis of Uncertain Cause

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