A fast and reliable LC-MS/MS method for simultaneous quantitation of fluoxetine and mirtazapine in human plasma

Author:

Alegete Pallavi12345,Kancherla Prasad6789,Albaseer Saeed S.1101112,Boodida Sathyanarayana123

Affiliation:

1. Department of Chemistry

2. JNTU College of Engineering Jagityal

3. Karimnagar, India

4. Spectrum Pharma Research Solutions

5. Hyderabad, India

6. Centre for Chemical Sciences & Technology

7. Institute of Science & Technology

8. Jawaharlal Nehru Technological University Hyderabad

9. , India

10. Faculty of Education

11. Thamar University

12. Thamar, Yemen

Abstract

A rapid and sensitive ultra-performance liquid chromatographic/tandem mass spectrometric assay (LC-MS/MS) was developed to simultaneously quantify fluoxetine and mirtazapine in human plasma using fluoxetine-D5 and olanzapine as internal standards (IS), respectively.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Reference21 articles.

1. Fluoxetine

2. A. C. Altamura and M. C.Mauri , in The use of fluoxetine in clinical practice , ed. A. Freeman , London, New York , Royal Society of Medicine Services , 1991 , Vol. 183 , pp. 53–59

3. A preliminary study of serotonergic antidepressants in treatment of dysthymia

4. Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology

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