Ginsenoside Rk1 improves endothelial function in diabetes through activating peroxisome proliferator-activated receptors-Reference-Cited by-同舟云学术

Ginsenoside Rk1 improves endothelial function in diabetes through activating peroxisome proliferator-activated receptors

Published:2024 Issue:10 Volume:15 Page:5485-5495
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Miao Lingchao¹,Zhou Yan¹,Tan Dechao¹²,Zhou Chunxiu¹,Ruan Cheng-Chao³,Wang Shengpeng¹²^ORCID,Wang Yitao¹²,Vong Chi Teng¹²,Cheang Wai San¹^ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China

2. Macau Centre for Research and Development in Chinese Medicine, University of Macau, Macau SAR, China

3. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, China

Abstract

Ginsenoside Rk1 activates three peroxisome proliferator-activated receptor (PPAR) isoforms to reduce reactive oxygen species (ROS) and increase nitric oxide (NO) release, thereby improving aortic endothelial function in diabetic obese mice.

Funder

Fundo para o Desenvolvimento das Ciências e da Tecnologia

Universidade de Macau

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO05222B

Reference44 articles.

1. Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

2. Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

3. The Role of PPARs in Disease

4. PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part I: PPAR-α

5. PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-β/δ and PPAR-γ

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