Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles-Reference-Cited by-同舟云学术

Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles

Published:2021 Issue:7 Volume:12 Page:1065-1120
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Kaushik Deepender¹²³⁴,Kaur Arshpreet¹²³⁴,Petrovsky Nikolai⁵⁶⁷⁸⁹^ORCID,Salunke Deepak B.¹²³⁴¹⁰^ORCID

Affiliation:

1. Department of Chemistry and Centre of Advanced Studies in Chemistry

2. Panjab University

3. Chandigarh 160014

4. India

5. Vaxine Pty Ltd

6. Warradale

7. Australia

8. College of Medicine and Public Health

9. Flinders University

10. National Interdisciplinary Centre of Vaccine, Immunotherapeutics and Antimicrobials

Abstract

TLR7/8 agonists are emerging as promising vaccine adjuvant candidates. An evolution of imidazole based TLR7/8 agonist from imidazoquinoline based scaffold is delineated along with the elaboration of detailed structure activity relationship (SAR) in each chemotype.

Funder

Ministry of Human Resource Development

National Institute of Allergy and Infectious Diseases

Global Connections Fund

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00031D

Reference113 articles.