Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment-Reference-Cited by-同舟云学术

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Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment

Published:2020 Issue:15 Volume:11 Page:3996-4006
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Bermejo Iris A.¹²³⁴⁵,Navo Claudio D.¹²³⁴⁵^ORCID,Castro-López Jorge⁶⁷⁸⁵,Guerreiro Ana⁹¹⁰¹¹¹²¹³,Jiménez-Moreno Ester¹²³⁴⁵,Sánchez Fernández Elena M.¹⁴¹⁵¹⁶¹⁷⁵,García-Martín Fayna¹⁸¹⁹²⁰²¹²²^ORCID,Hinou Hiroshi¹⁸¹⁹²⁰²¹²²,Nishimura Shin-Ichiro¹⁸¹⁹²⁰²¹²²^ORCID,García Fernández José M.²³²⁴²⁵⁵^ORCID,Mellet Carmen Ortiz¹⁴¹⁵¹⁶¹⁷⁵^ORCID,Avenoza Alberto¹²³⁴⁵,Busto Jesús H.¹²³⁴⁵,Bernardes Gonçalo J. L.⁹¹⁰¹¹¹²¹³^ORCID,Hurtado-Guerrero Ramón⁶⁷⁸⁵²⁶,Peregrina Jesús M.¹²³⁴⁵^ORCID,Corzana Francisco¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Química

2. Universidad de La Rioja

3. Centro de Investigación en Síntesis Química

4. E-26006 Logroño

5. Spain

6. Institute of Biocomputation and Physics of Complex Systems (BIFI)

7. University of Zaragoza

8. Zaragoza

9. Instituto de Medicina Molecular

10. Faculdade de Medicina

11. Universidade de Lisboa

12. 1649-028 Lisboa

13. Portugal

14. Departamento de Química Orgánica

15. Facultad de Química

16. Universidad de Sevilla

17. E-41012 Sevilla

18. Graduate School and Faculty of Advanced Life Science

19. Laboratory of Advanced Chemical Biology

20. Hokkaido University

21. Sapporo 001-0021

22. Japan

23. Instituto de Investigaciones Químicas (IIQ)

24. CSIC–Universidad de Sevilla

25. E-41092 Sevilla

26. Copenhagen Center for Glycomics

Abstract

An anti-cancer vaccine based on an unnatural antigen with an sp²-iminosugar fragment.

Funder

Agencia Estatal de Investigación

Ministerio de Ciencia, Innovación y Universidades

Ministerio de Economía y Competitividad

European Regional Development Fund

Royal Society

Fundación Científica Asociación Española Contra el Cáncer

Naito Foundation

Fundación Agencia Aragonesa para la Investigación y el Desarrollo

Gobierno de Aragón

Federación Española de Enfermedades Raras

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC06334J

Reference74 articles.

1. The Tn Antigen-Structural Simplicity and Biological Complexity

2. Mucins in cancer: function, prognosis and therapy

3. Latest developments in MUC1 immunotherapy

4. MUC1 (CD227): a multi-tasked molecule

5. Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis

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1. Synthesis, conformational analysis and GalNAc–lectin interactions of a constrained C-glycoside analogue of the T_N antigen;New Journal of Chemistry;2024

2. Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses;JACS Au;2023-11-21

3. High‐Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC‐SIGN and Langerin;Chemistry – A European Journal;2023-11-14

4. Reverse engineering the anti-MUC1 hybridoma antibody 139H2 by mass spectrometry-basedde novosequencing;2023-07-05

5. Immunomodulatory glycomedicine: Introducing next generation cancer glycovaccines;Biotechnology Advances;2023-07

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