Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry-Reference-Cited by-同舟云学术

Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry

Published:2017 Issue:1 Volume:8 Page:697-700
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kong A.¹²³⁴,Mancheno D. E.¹²³⁴,Boudet N.¹²³⁴,Delgado R.¹²³⁴,Andreansky E. S.¹²³⁴,Blakey S. B.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Emory University

3. Atlanta

4. USA

Abstract

A stereoselective cascade annulation reaction generates the tetracyclic core of the Malagasy alkaloids, facilitating the total synthesis of malagashanine.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03578G

Reference23 articles.

1. In Vitroandin VivoChloroquine-Potentiating Action ofStrychnos myrtoidesAlkaloids Against Chloroquine-Resistant Strains ofPlasmodiumMalaria

2. Effects of the naturally-occurring chemosensitizer malagashanine and its combination with chloroquine on KB and P388 cell lines and isolated auricle

3. Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria

4. Malagashanine potentiates chloroquine antimalarial activity in drug resistant Plasmodium malaria by modifying both its efflux and influx

5. Structure of malagashanine, a new alkaloid with chloroquine-potentiating action

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