A niobium-catalyzed coupling reaction of α-keto acids with ortho-phenylenediamines: synthesis of 3-arylquinoxalin-2(1H)-ones

Author:

Ebersol Camila1234,Rocha Nicole1234,Penteado Filipe1234ORCID,Silva Márcio S.1234ORCID,Hartwig Daniela1234ORCID,Lenardão Eder J.1234ORCID,Jacob Raquel G.1234ORCID

Affiliation:

1. LASOL - CCQFA

2. Universidade Federal de Pelotas - UFPel

3. Pelotas

4. Brazil

Abstract

A general methodology to access valuable 3-arylquinoxalin-2(1H)-ones was developed, by the reaction of α-keto acids with ortho-phenylenediamines in the presence of ammonium niobium oxalate (ANO) as a catalyst.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Financiadora de Estudos e Projetos

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

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3. A. R. Katritzky and C. W.Rees , Comprehensive Heterocyclic Chemistry , Pergamon Press , Oxford , 1984

4. A. R. Katritzky , C. W.Rees and E. F. V.Scriven , Comprehensive Heterocyclic Chemistry II , Pergamon Press , Oxford , 1996

5. Heterocycles in drugs and drug discovery

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